Buy Anabolic Steroids

How Does Glipizide Work?

Different medications are used to treat type 1 and type 2 diabetes. These medications have to be taken regularly and…(continue reading)

The number of people diagnosed with diabetes has increased at an alarming rate over the past few decades.

In fact, the American Diabetes Association has compared the growth rate of diabetes to an epidemic.

Currently, 34.2 million Americans are diagnosed with the disease and a large percentage of people are estimated to be undiagnosed. 

In many cases, the development of diabetes can be prevented by altering diet and making lifestyle changes like quitting smoking, getting more exercise and treating other conditions that may make you predisposed to diabetes, such as high blood pressure or cholesterol.

However, diabetes also has a large genetic component to its cause, which can predispose individuals to the disease if there is a family history of it. 

The main feature of diabetes is a high blood sugar level that cannot be reduced through normal functioning of the body.

There are two types of diabetes and both types are caused by a deficiency in the hormone, insulin, which moves sugar into cells to be converted into energy. In type 1 diabetes, the body cannot make insulin due to autoimmune reasons.

In type 2 diabetes, insulin that is produced is ineffective due to insufficient quantity or inability to function properly.

Both types of diabetes have no cure and must be treated to prevent other health risks from occurring. Untreated diabetes can lead to the following adverse conditions:

  • Blindness
  • Heart attack
  • Stroke
  • Kidney damage 
  • Nerve damage

Different medications are used to treat type 1 and type 2 diabetes. These medications have to be taken regularly and some of them must be taken life-long to manage the condition.

Glipizide is one medication that is used to treat type 2 diabetes. Since a combination of medications is usually prescribed for the treatment of diabetes, it can be confusing to understand how they work in helping to treat the condition.

Since diabetes drugs are one of the most commonly prescribed medications, we know a lot about how they work. 

cdc diabets infographic
CDC Diabetes Infographic

What is Glipizide?

The average patient needs to ask their doctor: “What is Glipizide?”

Glipizide is the generic name for the prescription brand names, Glucotrol and Glucotrol XL, made by the company Pfizer.

This medication is used to achieve glycemic control in patients with type 2 diabetes as a second-line treatment method after metformin.

Glipizide is not used on its own to treat type 1 diabetes.

The medication has a very fast absorption rate and pharmacological data has shown that the drug has complete bioavailability after taking it.

These features allow glipizide to start working faster compared to other diabetes medications in the same drug class. 

How does glipizide work?

According to the American Diabetes Association, there are nine different classes of diabetes drugs as treatment options to lower blood sugar.

Drugs within each class work in a similar way and each class has many drug options.

The major classes of drugs used to treat diabetes include alpha-glucosidase inhibitors, biguanides, bile acid sequestrants, dopamine-2 agonists, DPP-4 inhibitors, meglitinides, SGLT-2 inhibitors, sulfonylureas and thiazolidinediones (TZDs).

Often, a combination of drugs from different classes is used together to achieve effective control of blood sugar in diabetic patients. 

The Sulfonylureas

Glipizide belongs to the class of drugs called the sulfonylureas.

This class of drugs was discovered in the early 1940s by scientists studying the sulfonamide antibiotics. They observed that these antibiotics lowered blood sugar in animals that were given the drugs.

The sulfonylurea drugs used in diabetes treatment were developed based on this discovery, and there are currently three generations of sulfonylurea drugs.

Glipizide is a second-generation sulfonylurea medication along with other diabetes medications such as glyburide, gliclazide and glibornuride. The second-generation sulfonylureas were improved to have better potency. 

Glipizide is an ‘insulin secretagogue’ meaning that it stimulates the release of insulin from the beta islet cells of the pancreas where it is normally produced.

This increases the amount of insulin that enters the blood, which can then lower blood glucose levels by transporting it to cells for energy conversion.

The exact mechanism by which this happens involves a cascade of events. The sulfonylurea drugs bind to certain proteins on the beta-islet cells of the pancreas to reduce the passage of potassium ions in and out of the cells.

This event causes opening of calcium channels within the cell, allowing calcium ions to enter. An increased concentration of calcium ions in the cell stimulates the secretion of insulin.

This is the main mechanism through which glipizide works to lower blood glucose levels and its mode of action is dependent on the presence of functional beta-cells in the pancreas.

Research has also suggested that glipizide, like other sulfonylureas, can also inhibit the secretion of the hormone glucagon, which normally raises the amount of glucose in the blood through its regulation of metabolic pathways. 

Additionally, glipizide exerts its ability to lower blood glucose in other ways that do not directly involve the pancreas.

Research has found that the number of insulin receptors on different cell types, like fat cells and monocytes, are increased by the sulfonylurea drugs.

It has also been found that glipizide can suppress glucose production in the liver, a biological process that normally contributes to blood sugar levels.

This class of drugs also decreases the breakdown of fat in the liver. Overall, glipizide may also increase the body’s sensitivity to glucose intake and produce more insulin as a result. 

What to know when taking glipizide

Before taking glipizide, people with the following conditions should check with their doctor as taking the medication if you have ever had any of these conditions could be harmful. 

  • Diabetic ketoacidosis, a high level of ketones in the blood or urine, can occur in patients with both type 1 and type 2 diabetes that take glipizide. Glipizide is not indicated for the treatment of type 1 diabetes, but if you have type 2 diabetes and have ever had diabetic ketoacidosis, inform your doctor immediately. Taking glipizide could put you at increased risk for this condition, which can be fatal. 
  • Patients with chronic diarrhea or intestinal blockage should inform their doctor. 
  • People with a deficiency in the enzyme glucose-6-phosphate dehydrogenase (G6PD) should not take glipizide because it can causehemolytic anemia in these individuals.

Glipizide should be taken exactly as prescribed by your doctor. Usually, this  this diabetes medication is taken once a day in the morning before the first meal of the day.

The most common side effects that may occur when taking glipizide are digestive problems. These side effects include nausea, vomiting, diarrhea, constipation and headache. 

Hypoglycemia is also a serious side effect that is associated with taking glipizide. If you take other medications for diabetes that lower blood sugar, the risk of hypoglycemia is higher.

It is important to recognize the signs of hypoglycemia like excessive sweating, hunger, headache, weakness, blurry vision and feeling dizzy.

If hypoglycemia is not addressed immediately when symptoms begin, it can be dangerous.

If you experience the symptoms of hypoglycemia while taking glipizide, you can drink or eat something with sugar in it such as candy or juice, but if symptoms persist, urgent medical attention is required.

Some commonly taken drugs, like the non-steroid anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen and aspirin can also cause low blood sugar to occur if they’re taken along with glipizide.

Similarly, some blood pressure medication and blood thinners can also cause low blood sugar in combination with glipizide.

Other medications may cause glipizide to be less effective and high blood sugar may result. Be sure to check with your doctor on whether any medications that you currently take could interfere with glipizide.

Pregnant women should also check with their doctor before taking glipizide. Usually, other classes of diabetes medications are preferred for women during pregnancy. 

How to buy glipizide

Glipizide is available as a generic medication or the brand name drugs, Glucotrol or Glucotrol XL.

Glipizide is also available as a combination oral tablet with metformin, named metaglip.

Metformin belongs to the biguanide class of diabetes drugs, so the combination of both drugs together can work in different ways to bring about an overall reduction in blood sugar levels.

This is a good example of how medications from the different classes of drugs used to treat diabetes are used together.

By itself, generic glipizide is relatively inexpensive.

This is good news for a second- line treatment drug used to treat diabetes, as many patients can afford to purchase their medication regularly.

This card is completely free of cost and can help you get additional savings on glipizide, as well as any other FDA approved medications you may be taking for diabetes or other conditions

Keep in mind that medications used to treat diabetes are just one component of a treatment regimen of which dietary changes and exercise are also equally important to control the condition.

By following the treatment method that is personally recommended for you, living with the diabetes can become less challenging

References and Sources:



Fact Checked and Editorial Process is devoted to producing expert and accurate articles and information for our readers by hiring experts, journalists, medical professionals, and our growing community. We encourage you to read more about our content, editing, and fact checking methods here. This was fact checked by Erik Rivera and medically reviewed by Dr. Angel Rivera.

fact checked and medically reviewed

We are committed to providing our readers with only trusted resources and science-based studies with regards to medication and health information. 

Disclaimer: This general information is not intended to diagnose any medical condition or to replace your healthcare professional. If you suspect medical problems or need medical help or advice, please talk with your healthcare professional.

Metformin Diabetes: Unmasking the Truth Behind This Commonly Prescribed Drug

Metformin, a commonly prescribed medication, has long been the go-to treatment for millions of people around the globe managing their type 2 diabetes. We’re going to delve into why this is the case, discussing its efficacy, benefits, and potential side effects. Our goal is to provide accurate information about metformin and its role in the management of diabetes.

Read More »

Diabetes Dizziness: Unraveling the Causes and Solutions

We’ve all experienced that light-headed, spinning sensation at some point. It’s disconcerting, to say the least. However, when this feeling becomes a common occurrence for individuals with diabetes, it’s time to take notice and understand why. Diabetes dizziness is not just an inconvenient symptom; it can be a sign of underlying complications associated with this prevalent disease.

Read More »

Apple for Diabetes: Uncovering the Potential Health Benefits

When managing diabetes, every bite counts. What we choose to put on our plates can have a significant impact on our blood sugar levels, and ultimately, our overall health. Apples, often hailed as a superfood for their numerous health benefits, are frequently part of the conversation when discussing diabetes-friendly diets.

Read More »

Weight Loss Drug Diabetes: Unveiling the Latest Breakthroughs and Advancements

We’re living in an era where health issues like obesity and diabetes are prevalent. The struggle with weight loss is a common one, and finding the right solution can often feel overwhelming. It’s become vital to explore all avenues for maintaining a healthy lifestyle– including the use of weight loss drugs that could potentially aid in managing diabetes.

Read More »

Peanut Butter and Diabetes: Unraveling the Connection

Living with diabetes can sometimes feel like walking a dietary tightrope. It’s an ongoing balancing act between what we’d love to eat and what our bodies need us to consume in order to maintain optimal blood sugar levels. One such food item that often raises questions is peanut butter. Is it good or bad for people managing their diabetes?

Read More »

Natural Remedy for Diabetes: Exploring Effective Herbal Solutions

When it comes to managing diabetes, we all recognize the importance of a balanced diet and regular exercise. But did you know there’s also a range of natural remedies that can help keep your blood sugar levels in check? From everyday spices in your kitchen cupboard to certain types of exercise, these remedies offer an added layer of control over this challenging condition.

Read More »

How is Gestational Diabetes Diagnosed: A Comprehensive Guide on the Key Procedures

When it comes to pregnancy, there are several health concerns to be aware of, including the condition known as gestational diabetes. Gestational diabetes is a temporary condition that occurs in certain women during pregnancy. Although it typically disappears after giving birth, it is vital to effectively diagnose and manage it throughout pregnancy to ensure the well-being of both the mother and the baby. Learn more about how is gestational diabetes diagnosed and its importance in pregnancy health.

Read More »

Best Supplement for Diabetes: Unveiling the Top Choice for Optimal Health

There’s a growing interest in the role of dietary supplements in managing diabetes. Supplements for diabetes aren’t a cure-all, but they can be part of an overall strategy to keep blood sugar levels in check. We’ll delve into this topic, exploring some of the best supplements to consider if you’re dealing with this increasingly common condition.

Read More »
Visit Our Shop

Top Rated and Approved Diabetic Products at Cheap Prices.

Visit our Shop Today and Start Saving Hundreds on Your Diabetic Supplies and Products.

Top Destinations

Recent Articles

Stay in Touch

Share On

Leave a Reply

Join Our Newsletter

Get exclusive offers, advice, and tips from delivered to your inbox.